A Secret Weapon For ceesdekker.net
A Secret Weapon For ceesdekker.net
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‘Certainly, which is about ideal. I hunt for a Actual physical understanding of biological units in a very bottom-up way. I believe you could possibly distinguish three strains of investigation in my group at the moment. The primary issues chromosome composition: how do you get a metre-extended DNA polymer folded and organised in this type of microscopic mobile? We've produced visualisation tactics that allow for us to study how, for instance, SMC proteins loop DNA (movie on Youtube) as a way to Construct up chromosomes.
But how can morality, the dignity of the individual, my expertise on the that means of existence, observe from the motion of atoms? A purely naturalistic perspective fails here; a Christian viewpoint, I believe, is a much more sensible approach to interpret these components of fact.’
, Groningen researchers current the outcome of their initiatives to generate labs much more sustainable and provide tips for other labs.
Because 2000, Dekker has shifted the primary focus of his operate toward biophysics the place he reports the Houses of solitary biomolecules and cells utilizing the equipment of nanotechnology. This modification of industry was driven by his fascination with the exceptional performing of biological molecular buildings, and through the extensive-phrase perspective that lots of fascinating discoveries can be expected On this field.[five] Present-day lines of study in his biophysics team are in the parts of:[six]
This yielded a breakthrough. Inside of only a few months, we ended up capable of measure transport via someone single-walled carbon nanotube. Dependant on small-temperature experiments by a superb PhD student in my group, Sander Tans (now a valued colleague and professor at Delft College of Know-how with the active investigate lab at AMOLF in Amsterdam), we confirmed that carbon nanotubes were authentic quantum wires with really long (micrometres) Digital coherence lengths — confirming theoretical predictions of metallic conduct.
Microbiology has only been around for a century, given that we started to analyze micro-organisms a lot more critically. I believed nanobiology was an ideal time period, because all molecular Organic relevant interactions take place for the nanoscale: a protein is a handful of nanometres in size, DNA is two nm thick.’
Numerous associated developments followed, exactly where our group set up distinct transistor variants for example solitary-electron transistors at place temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled many transistors into compact evidence-of-theory Digital circuits.
He also identified time to put in writing quite a few books, send out Just about forty thousand tweets and lead An effective study group at Delft University of Engineering. ‘It doesn’t really feel like get the job done’, he states. ‘I’m just terribly curious.’
Understanding basic processes regulating the spatial and dynamic organisation in the DNA in Dwell cells.
Resolving the move sizing in condensin-pushed DNA loop extrusion identifies ATP binding as being the action-making course of action
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Nanoscientist Cees Dekker can be an amiable and flamboyant male who seems Significantly younger compared to the sixty two yrs he essentially is – modern glasses, psychedelic shirt, participating smile – although not one to waste time. He will take his time, but no more than important.
Such as, we consider the nucleopore sophisticated, a gateway in between the mobile nucleus and also the cytoplasm. This is a very sophisticated method and as a consequence challenging to analyze in a very cell, so we use biomimetics. We reconstruct holes then insert individual features on the nucleopore complicated to review transportation by means of it at the single-molecule amount.’
At last, I'll briefly sketch many of our ideas to discover the creating of synthetic cells, exclusively our 1st techniques to determine artificial cell division.